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Co-labelling for the motor neuron marker choline acetyl-transferase and for SMN revealed that at 1 month of age, an age prior to development of pathology or abnormal motor phenotypes, expression of mutant R521C had already provoked a slight reduction of Gems (Fig

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[DOI] [PubMed] [Google Scholar] 9.Sedlacek H., Czech J., Naik R., Kaur G., Worland P., Losiewicz M., Parker B., Carlson B., Smith A., Senderowicz A., et al