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Melatonin Attenuates Early Brain Injury via the Melatonin Receptor/Sirt1/NF-ΚB Signaling Pathway Following Subarachnoid Hemorrhage in Mice

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The first active site catalyzes the release of the amide nitrogen from glutamine as an ammonium ion, which enters the tunnel and reaches the second active site, where it is combined with bicarbonate, at the expense of ATP, to yield carbamate